Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis-Microbiological Profile, Biofilm-Forming Capacity and Histology
![](/themes/Miragereponivs//images/openAccess.png)
2022
Authors
Kostić, Marina![](/themes/Miragereponivs/images/orcid.png)
Ivanov, Marija
![](/themes/Miragereponivs/images/orcid.png)
Sankovic-Babić, Snežana
Tepavcević, Zvezdana
![](/themes/Miragereponivs/images/orcid.png)
Radanović, Oliver
![](/themes/Miragereponivs/images/orcid.png)
Soković, Marina
![](/themes/Miragereponivs/images/orcid.png)
Cirić, Ana
![](/themes/Miragereponivs/images/orcid.png)
Article (Published version)
Metadata
Show full item recordAbstract
Chronic tonsillitis (CT) is a global health issue which can impair patient's quality of life and has an important socioeconomic impact due to the nonrational use of antibiotics, increased antimicrobial resistance and frequent need for surgical treatment. In order to isolate and identify the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained from the ENT Clinic, KBC Zvezdara, Belgrade, Serbia. Culture identification was performed by MALDI-TOF MS and the Staphylococcus aureus isolates were tested for biofilm forming capability and antibiotic susceptibility. Additionally, a histological examination of palatine and adenoid tissue was performed in order to detect the presence of CT-causing bacteria. The slight majority of participants were females with median age of 28 years for adult patients (group I) and 6 years for children (group II). Analysis of the incidence of bacteria isolated from tissue samples in both groups showed the highest pre...valence of S. aureus, Streptococcus oralis and Streptococcus parasanquinis. In addition to interfollicular hyperplasia, colonies of species S. aureus were detected in histological material. The presence of biofilm might be the reason for the recurrence of infection. Therefore, searching for a new treatment of CT is of great importance.
Keywords:
Staphylococcus aureus / histology / chronic tonsillitis / biofilmSource:
Antibiotics-Basel, 2022, 11, 12Publisher:
- MDPI, Basel
Funding / projects:
- Serbian Ministry of Education, Science and Technological Development
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/antibiotics11121747
ISSN: 2079-6382
PubMed: 36551404
WoS: 000900490000001
Scopus: 2-s2.0-85144716878
Collections
Institution/Community
Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Kostić, Marina AU - Ivanov, Marija AU - Sankovic-Babić, Snežana AU - Tepavcević, Zvezdana AU - Radanović, Oliver AU - Soković, Marina AU - Cirić, Ana PY - 2022 UR - https://reponivs.nivs.rs/handle/123456789/480 AB - Chronic tonsillitis (CT) is a global health issue which can impair patient's quality of life and has an important socioeconomic impact due to the nonrational use of antibiotics, increased antimicrobial resistance and frequent need for surgical treatment. In order to isolate and identify the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained from the ENT Clinic, KBC Zvezdara, Belgrade, Serbia. Culture identification was performed by MALDI-TOF MS and the Staphylococcus aureus isolates were tested for biofilm forming capability and antibiotic susceptibility. Additionally, a histological examination of palatine and adenoid tissue was performed in order to detect the presence of CT-causing bacteria. The slight majority of participants were females with median age of 28 years for adult patients (group I) and 6 years for children (group II). Analysis of the incidence of bacteria isolated from tissue samples in both groups showed the highest prevalence of S. aureus, Streptococcus oralis and Streptococcus parasanquinis. In addition to interfollicular hyperplasia, colonies of species S. aureus were detected in histological material. The presence of biofilm might be the reason for the recurrence of infection. Therefore, searching for a new treatment of CT is of great importance. PB - MDPI, Basel T2 - Antibiotics-Basel T1 - Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis-Microbiological Profile, Biofilm-Forming Capacity and Histology IS - 12 VL - 11 DO - 10.3390/antibiotics11121747 UR - conv_594 ER -
@article{ author = "Kostić, Marina and Ivanov, Marija and Sankovic-Babić, Snežana and Tepavcević, Zvezdana and Radanović, Oliver and Soković, Marina and Cirić, Ana", year = "2022", abstract = "Chronic tonsillitis (CT) is a global health issue which can impair patient's quality of life and has an important socioeconomic impact due to the nonrational use of antibiotics, increased antimicrobial resistance and frequent need for surgical treatment. In order to isolate and identify the causing agents of CT, a total of 79 postoperative palatine and adenoid tissue samples were obtained from the ENT Clinic, KBC Zvezdara, Belgrade, Serbia. Culture identification was performed by MALDI-TOF MS and the Staphylococcus aureus isolates were tested for biofilm forming capability and antibiotic susceptibility. Additionally, a histological examination of palatine and adenoid tissue was performed in order to detect the presence of CT-causing bacteria. The slight majority of participants were females with median age of 28 years for adult patients (group I) and 6 years for children (group II). Analysis of the incidence of bacteria isolated from tissue samples in both groups showed the highest prevalence of S. aureus, Streptococcus oralis and Streptococcus parasanquinis. In addition to interfollicular hyperplasia, colonies of species S. aureus were detected in histological material. The presence of biofilm might be the reason for the recurrence of infection. Therefore, searching for a new treatment of CT is of great importance.", publisher = "MDPI, Basel", journal = "Antibiotics-Basel", title = "Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis-Microbiological Profile, Biofilm-Forming Capacity and Histology", number = "12", volume = "11", doi = "10.3390/antibiotics11121747", url = "conv_594" }
Kostić, M., Ivanov, M., Sankovic-Babić, S., Tepavcević, Z., Radanović, O., Soković, M.,& Cirić, A.. (2022). Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis-Microbiological Profile, Biofilm-Forming Capacity and Histology. in Antibiotics-Basel MDPI, Basel., 11(12). https://doi.org/10.3390/antibiotics11121747 conv_594
Kostić M, Ivanov M, Sankovic-Babić S, Tepavcević Z, Radanović O, Soković M, Cirić A. Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis-Microbiological Profile, Biofilm-Forming Capacity and Histology. in Antibiotics-Basel. 2022;11(12). doi:10.3390/antibiotics11121747 conv_594 .
Kostić, Marina, Ivanov, Marija, Sankovic-Babić, Snežana, Tepavcević, Zvezdana, Radanović, Oliver, Soković, Marina, Cirić, Ana, "Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis-Microbiological Profile, Biofilm-Forming Capacity and Histology" in Antibiotics-Basel, 11, no. 12 (2022), https://doi.org/10.3390/antibiotics11121747 ., conv_594 .