First Report on the Efficiency of Oral Vaccination of Foxes against Rabies in Serbia
Authorized Users Only
2015
Authors
Lupulović, D.Maksimović Zorić, Jelena
Vasković, N.
Bugarski, Dejan
Plavsić, Budimir
Ivanović, N.
Petrović, Tamaš
Pusić, I.
Marčić, Doroteja
Grgić, Z.
Lazić, S.
Article (Published version)
Metadata
Show full item recordAbstract
Rabies is one of the oldest known zoonotic diseases that has significant impact on public health, but still remains neglected in Serbia. Rabies virus can infect humans and other mammals and causes inflammation of the brain associated with encephalomyelitis and neurological symptoms. In 2010, Veterinary Directorate (national Competent Authority for animal health in Serbia) has started multi-annual project of oral rabies vaccination of foxes and other wild carnivores (e.g. jackals), as support of long-term programme of eradication of rabies in Serbia, co-funded by EU (financed by Instrument for Pre-Accession Assistance). Monitoring of the effectiveness of oral vaccination campaigns has been carried out in continuation from 2011 and was based on: (i) post-mortem laboratory examination of brain tissue of target animals (foxes, jackals and other carnivores) by fluorescent antibody test (FAT), (ii) detection of antibodies against rabies virus in serum samples by ELISA and (iii) detection of ...tetracycline biomarker in the mandibles for the evaluation of vaccine bait uptake. From September 2011 to May 2014, the total number of 4943 brain tissue samples, 4241 sera and 4971 mandibles were analysed. Confirmed rabies-positive brains decreased from 10 in 2011/2012 to 6 in 2012/2013 and eventually to 1 positive case in 2013/2014. The sero-conversion rate increased from 10.48% (133/1269) in 2011/2012 to 20.11% (362/1800) in 2012/2013 and 42.23% (495/1172) in 2013/2014. Along with the sero-conversion, the number of detected tetracycline-positive mandibles demonstrated an increasing tendency in the same period, being 49.67% (682/1373) in 2011/2012, 62.60% (1294/2067) in 2012/2013 and 90.33% (1383/1531) in the monitoring programme carried out in 2013/2014. Presented results confirmed that ORV of foxes and other wildlife in Serbia against rabies was successful and characterized by steady increase of vaccine baits uptake and immunization of animals.
Keywords:
Rabies / oral vaccination / monitoring / fox / eliminationSource:
Zoonoses and Public Health, 2015, 62, 8, 625-636Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
- Veterinary Directorate, Ministry of Agriculture and Environmental Protection of the Republic of Serbia
- EU IPA projects
- Wild animal health monitoring and introduction of new biotechnology procedures in detection of infectious and zoonotic agents - risk analysis for human health, domestic and wild animal health and for environmental contamination (RS-MESTD-Technological Development (TD or TR)-31084)
DOI: 10.1111/zph.12196
ISSN: 1863-1959
PubMed: 25903646
WoS: 000367884000007
Scopus: 2-s2.0-84958841319
Collections
Institution/Community
Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Lupulović, D. AU - Maksimović Zorić, Jelena AU - Vasković, N. AU - Bugarski, Dejan AU - Plavsić, Budimir AU - Ivanović, N. AU - Petrović, Tamaš AU - Pusić, I. AU - Marčić, Doroteja AU - Grgić, Z. AU - Lazić, S. PY - 2015 UR - https://reponivs.nivs.rs/handle/123456789/290 AB - Rabies is one of the oldest known zoonotic diseases that has significant impact on public health, but still remains neglected in Serbia. Rabies virus can infect humans and other mammals and causes inflammation of the brain associated with encephalomyelitis and neurological symptoms. In 2010, Veterinary Directorate (national Competent Authority for animal health in Serbia) has started multi-annual project of oral rabies vaccination of foxes and other wild carnivores (e.g. jackals), as support of long-term programme of eradication of rabies in Serbia, co-funded by EU (financed by Instrument for Pre-Accession Assistance). Monitoring of the effectiveness of oral vaccination campaigns has been carried out in continuation from 2011 and was based on: (i) post-mortem laboratory examination of brain tissue of target animals (foxes, jackals and other carnivores) by fluorescent antibody test (FAT), (ii) detection of antibodies against rabies virus in serum samples by ELISA and (iii) detection of tetracycline biomarker in the mandibles for the evaluation of vaccine bait uptake. From September 2011 to May 2014, the total number of 4943 brain tissue samples, 4241 sera and 4971 mandibles were analysed. Confirmed rabies-positive brains decreased from 10 in 2011/2012 to 6 in 2012/2013 and eventually to 1 positive case in 2013/2014. The sero-conversion rate increased from 10.48% (133/1269) in 2011/2012 to 20.11% (362/1800) in 2012/2013 and 42.23% (495/1172) in 2013/2014. Along with the sero-conversion, the number of detected tetracycline-positive mandibles demonstrated an increasing tendency in the same period, being 49.67% (682/1373) in 2011/2012, 62.60% (1294/2067) in 2012/2013 and 90.33% (1383/1531) in the monitoring programme carried out in 2013/2014. Presented results confirmed that ORV of foxes and other wildlife in Serbia against rabies was successful and characterized by steady increase of vaccine baits uptake and immunization of animals. PB - Wiley-Blackwell, Hoboken T2 - Zoonoses and Public Health T1 - First Report on the Efficiency of Oral Vaccination of Foxes against Rabies in Serbia EP - 636 IS - 8 SP - 625 VL - 62 DO - 10.1111/zph.12196 UR - conv_457 ER -
@article{ author = "Lupulović, D. and Maksimović Zorić, Jelena and Vasković, N. and Bugarski, Dejan and Plavsić, Budimir and Ivanović, N. and Petrović, Tamaš and Pusić, I. and Marčić, Doroteja and Grgić, Z. and Lazić, S.", year = "2015", abstract = "Rabies is one of the oldest known zoonotic diseases that has significant impact on public health, but still remains neglected in Serbia. Rabies virus can infect humans and other mammals and causes inflammation of the brain associated with encephalomyelitis and neurological symptoms. In 2010, Veterinary Directorate (national Competent Authority for animal health in Serbia) has started multi-annual project of oral rabies vaccination of foxes and other wild carnivores (e.g. jackals), as support of long-term programme of eradication of rabies in Serbia, co-funded by EU (financed by Instrument for Pre-Accession Assistance). Monitoring of the effectiveness of oral vaccination campaigns has been carried out in continuation from 2011 and was based on: (i) post-mortem laboratory examination of brain tissue of target animals (foxes, jackals and other carnivores) by fluorescent antibody test (FAT), (ii) detection of antibodies against rabies virus in serum samples by ELISA and (iii) detection of tetracycline biomarker in the mandibles for the evaluation of vaccine bait uptake. From September 2011 to May 2014, the total number of 4943 brain tissue samples, 4241 sera and 4971 mandibles were analysed. Confirmed rabies-positive brains decreased from 10 in 2011/2012 to 6 in 2012/2013 and eventually to 1 positive case in 2013/2014. The sero-conversion rate increased from 10.48% (133/1269) in 2011/2012 to 20.11% (362/1800) in 2012/2013 and 42.23% (495/1172) in 2013/2014. Along with the sero-conversion, the number of detected tetracycline-positive mandibles demonstrated an increasing tendency in the same period, being 49.67% (682/1373) in 2011/2012, 62.60% (1294/2067) in 2012/2013 and 90.33% (1383/1531) in the monitoring programme carried out in 2013/2014. Presented results confirmed that ORV of foxes and other wildlife in Serbia against rabies was successful and characterized by steady increase of vaccine baits uptake and immunization of animals.", publisher = "Wiley-Blackwell, Hoboken", journal = "Zoonoses and Public Health", title = "First Report on the Efficiency of Oral Vaccination of Foxes against Rabies in Serbia", pages = "636-625", number = "8", volume = "62", doi = "10.1111/zph.12196", url = "conv_457" }
Lupulović, D., Maksimović Zorić, J., Vasković, N., Bugarski, D., Plavsić, B., Ivanović, N., Petrović, T., Pusić, I., Marčić, D., Grgić, Z.,& Lazić, S.. (2015). First Report on the Efficiency of Oral Vaccination of Foxes against Rabies in Serbia. in Zoonoses and Public Health Wiley-Blackwell, Hoboken., 62(8), 625-636. https://doi.org/10.1111/zph.12196 conv_457
Lupulović D, Maksimović Zorić J, Vasković N, Bugarski D, Plavsić B, Ivanović N, Petrović T, Pusić I, Marčić D, Grgić Z, Lazić S. First Report on the Efficiency of Oral Vaccination of Foxes against Rabies in Serbia. in Zoonoses and Public Health. 2015;62(8):625-636. doi:10.1111/zph.12196 conv_457 .
Lupulović, D., Maksimović Zorić, Jelena, Vasković, N., Bugarski, Dejan, Plavsić, Budimir, Ivanović, N., Petrović, Tamaš, Pusić, I., Marčić, Doroteja, Grgić, Z., Lazić, S., "First Report on the Efficiency of Oral Vaccination of Foxes against Rabies in Serbia" in Zoonoses and Public Health, 62, no. 8 (2015):625-636, https://doi.org/10.1111/zph.12196 ., conv_457 .