Melamine-induced nephrotoxicity in weaned piglets in Serbia
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2014
Authors
Kureljušić, BranislavIvetić, Vojin
Savić, Božidar
Kureljušić, Jasna
Jezdimirović, Nemanja
Cvetojević, Đorđe
Vesković-Moračanin, Slavica
Stefanović, Srđan
Juntes, Polona
Jakić-Dimić, Dobrila
Article (Published version)
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Melamine is not approved for use in animal feed, although evidence of melamine poisoning in pigs has been found. Melamine in animal feed can induce nephrolithiasis, chronic kidney inflammation, bladder carcinoma and even death in animals. In September 2011, nine hundred 40-60-day-old piglets from a commercial finishing farm in Serbia developed anorexia, wasting, polydipsia and lethargy. At necropsy, the main macroscopic finding in ten necropsied piglets was observed on the kidneys. The kidneys were slightly enlarged and firm in consistency. The cortical surface was wrinkled, with a diffuse distribution of the yellow foci in the cortex and medulla. Microscopically, these yellow foci were accumulations of crystals located predominantly within the lumina of the dilated distal straight and convoluted tubules and collecting ducts. The crystals appeared variable and birefringent when viewed under polarized light. Two types of crystals were observed: the first type had several dark striations... radiating from the eosinophilic round centre, while the second type consisted of pale green to brown irregular striated aggregates without an eosinophilic centre. In all cases, multifocally, there were moderate aggregates of lymphocytes, plasma cells, macrophages and multinucleated giant cells within the interstitium. From the clinical signs, necropsy findings, histochemical and toxicological results, it was concluded that melamine-contaminated feed was the primary cause of nephrotoxicity and death in the observed piglets. To our knowledge, this is the first report of melamine poisoning in pigs in Serbia.
Keywords:
weaned piglets / nephrotoxicity / melamine / kidneySource:
Slovenian Veterinary Research, 2014, 51, 3, 141-146Publisher:
- University of Ljubljana - Veterinary Faculty
Funding / projects:
- Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
- Improvement of productivity and welfare of dairy cows by indentification and exclusion of stress factors (RS-MESTD-Technological Development (TD or TR)-31062)
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Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Kureljušić, Branislav AU - Ivetić, Vojin AU - Savić, Božidar AU - Kureljušić, Jasna AU - Jezdimirović, Nemanja AU - Cvetojević, Đorđe AU - Vesković-Moračanin, Slavica AU - Stefanović, Srđan AU - Juntes, Polona AU - Jakić-Dimić, Dobrila PY - 2014 UR - https://reponivs.nivs.rs/handle/123456789/281 AB - Melamine is not approved for use in animal feed, although evidence of melamine poisoning in pigs has been found. Melamine in animal feed can induce nephrolithiasis, chronic kidney inflammation, bladder carcinoma and even death in animals. In September 2011, nine hundred 40-60-day-old piglets from a commercial finishing farm in Serbia developed anorexia, wasting, polydipsia and lethargy. At necropsy, the main macroscopic finding in ten necropsied piglets was observed on the kidneys. The kidneys were slightly enlarged and firm in consistency. The cortical surface was wrinkled, with a diffuse distribution of the yellow foci in the cortex and medulla. Microscopically, these yellow foci were accumulations of crystals located predominantly within the lumina of the dilated distal straight and convoluted tubules and collecting ducts. The crystals appeared variable and birefringent when viewed under polarized light. Two types of crystals were observed: the first type had several dark striations radiating from the eosinophilic round centre, while the second type consisted of pale green to brown irregular striated aggregates without an eosinophilic centre. In all cases, multifocally, there were moderate aggregates of lymphocytes, plasma cells, macrophages and multinucleated giant cells within the interstitium. From the clinical signs, necropsy findings, histochemical and toxicological results, it was concluded that melamine-contaminated feed was the primary cause of nephrotoxicity and death in the observed piglets. To our knowledge, this is the first report of melamine poisoning in pigs in Serbia. PB - University of Ljubljana - Veterinary Faculty T2 - Slovenian Veterinary Research T1 - Melamine-induced nephrotoxicity in weaned piglets in Serbia EP - 146 IS - 3 SP - 141 VL - 51 UR - conv_669 ER -
@article{ author = "Kureljušić, Branislav and Ivetić, Vojin and Savić, Božidar and Kureljušić, Jasna and Jezdimirović, Nemanja and Cvetojević, Đorđe and Vesković-Moračanin, Slavica and Stefanović, Srđan and Juntes, Polona and Jakić-Dimić, Dobrila", year = "2014", abstract = "Melamine is not approved for use in animal feed, although evidence of melamine poisoning in pigs has been found. Melamine in animal feed can induce nephrolithiasis, chronic kidney inflammation, bladder carcinoma and even death in animals. In September 2011, nine hundred 40-60-day-old piglets from a commercial finishing farm in Serbia developed anorexia, wasting, polydipsia and lethargy. At necropsy, the main macroscopic finding in ten necropsied piglets was observed on the kidneys. The kidneys were slightly enlarged and firm in consistency. The cortical surface was wrinkled, with a diffuse distribution of the yellow foci in the cortex and medulla. Microscopically, these yellow foci were accumulations of crystals located predominantly within the lumina of the dilated distal straight and convoluted tubules and collecting ducts. The crystals appeared variable and birefringent when viewed under polarized light. Two types of crystals were observed: the first type had several dark striations radiating from the eosinophilic round centre, while the second type consisted of pale green to brown irregular striated aggregates without an eosinophilic centre. In all cases, multifocally, there were moderate aggregates of lymphocytes, plasma cells, macrophages and multinucleated giant cells within the interstitium. From the clinical signs, necropsy findings, histochemical and toxicological results, it was concluded that melamine-contaminated feed was the primary cause of nephrotoxicity and death in the observed piglets. To our knowledge, this is the first report of melamine poisoning in pigs in Serbia.", publisher = "University of Ljubljana - Veterinary Faculty", journal = "Slovenian Veterinary Research", title = "Melamine-induced nephrotoxicity in weaned piglets in Serbia", pages = "146-141", number = "3", volume = "51", url = "conv_669" }
Kureljušić, B., Ivetić, V., Savić, B., Kureljušić, J., Jezdimirović, N., Cvetojević, Đ., Vesković-Moračanin, S., Stefanović, S., Juntes, P.,& Jakić-Dimić, D.. (2014). Melamine-induced nephrotoxicity in weaned piglets in Serbia. in Slovenian Veterinary Research University of Ljubljana - Veterinary Faculty., 51(3), 141-146. conv_669
Kureljušić B, Ivetić V, Savić B, Kureljušić J, Jezdimirović N, Cvetojević Đ, Vesković-Moračanin S, Stefanović S, Juntes P, Jakić-Dimić D. Melamine-induced nephrotoxicity in weaned piglets in Serbia. in Slovenian Veterinary Research. 2014;51(3):141-146. conv_669 .
Kureljušić, Branislav, Ivetić, Vojin, Savić, Božidar, Kureljušić, Jasna, Jezdimirović, Nemanja, Cvetojević, Đorđe, Vesković-Moračanin, Slavica, Stefanović, Srđan, Juntes, Polona, Jakić-Dimić, Dobrila, "Melamine-induced nephrotoxicity in weaned piglets in Serbia" in Slovenian Veterinary Research, 51, no. 3 (2014):141-146, conv_669 .