Assessment of toxic elements' content in swine kidneys: Pathomorphological analysis
2010
Preuzimanje 🢃
Autori
Milićević, Dragan R.Jovanović, Milijan
Jurić, Verica B.
Petrović, Zoran I.
Vuković, Dubravka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background: In order to ensure the safety of consumers in Serbia, the toxic elements' (Cd, Hg, As, Pb) content in swine kidneys collected from three different sites in Serbia (n=90), were determined by atomic absorption spectrometry. Also, in order to find information on the effects of accumulation of toxic elements in swine kidneys, histopathological examination of kidneys was carried out. Methods: Determination of toxic elements (Cd, Hg, As, Pb) in swine kidneys was performed by atomic absorption spectrometry. For microscopic examination, kidney samples were fixed in 10% neutral buffered formalin and absolute alcohol for 5 to 7 days, processed by routine methods, sectioned at 5-8 μm, and stained with hematoxylin and eosin (HE) for light microscopy. Results: The presence of mercury was found in 33.3% of kidney samples in the range of 0.005-0.055 mg/kg, while presence of cadmium was found in less degree (27.7%) but in higher content (0.05-1,23 mg/kg). The presence of arsenic was found ...only in one sample, while presence of lead was not found. The metal-to-metal correlation analysis supported the theory that there were different sources of contamination. Histopathological examination of kidneys confirms tubulopathies with edema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules' cells were found. Conclusion: This study shows the presence of toxic elements in pigs butchered in Serbia at levels comparable to those reported in other countries., and consequently do not represent any concern from a consumer safety point of view. The lack of strong correlation between histopathological changes and incidence of toxic elements found in our trial may explain the possible synergism among toxic elements and other nephrotoxic compounds, which enhances the toxicity, especially in cases of low contamination.
Ključne reči:
Swine / Risk Assessment / Mercury / Lead / Kidney / Food Contamination / Cadmium / ArsenicIzvor:
Archive of Oncology, 2010, 18, 1-2, 17-22Izdavač:
- Institut za onkologiju, Sremska Kamenica
Institucija/grupa
Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Milićević, Dragan R. AU - Jovanović, Milijan AU - Jurić, Verica B. AU - Petrović, Zoran I. AU - Vuković, Dubravka PY - 2010 UR - https://reponivs.nivs.rs/handle/123456789/145 AB - Background: In order to ensure the safety of consumers in Serbia, the toxic elements' (Cd, Hg, As, Pb) content in swine kidneys collected from three different sites in Serbia (n=90), were determined by atomic absorption spectrometry. Also, in order to find information on the effects of accumulation of toxic elements in swine kidneys, histopathological examination of kidneys was carried out. Methods: Determination of toxic elements (Cd, Hg, As, Pb) in swine kidneys was performed by atomic absorption spectrometry. For microscopic examination, kidney samples were fixed in 10% neutral buffered formalin and absolute alcohol for 5 to 7 days, processed by routine methods, sectioned at 5-8 μm, and stained with hematoxylin and eosin (HE) for light microscopy. Results: The presence of mercury was found in 33.3% of kidney samples in the range of 0.005-0.055 mg/kg, while presence of cadmium was found in less degree (27.7%) but in higher content (0.05-1,23 mg/kg). The presence of arsenic was found only in one sample, while presence of lead was not found. The metal-to-metal correlation analysis supported the theory that there were different sources of contamination. Histopathological examination of kidneys confirms tubulopathies with edema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules' cells were found. Conclusion: This study shows the presence of toxic elements in pigs butchered in Serbia at levels comparable to those reported in other countries., and consequently do not represent any concern from a consumer safety point of view. The lack of strong correlation between histopathological changes and incidence of toxic elements found in our trial may explain the possible synergism among toxic elements and other nephrotoxic compounds, which enhances the toxicity, especially in cases of low contamination. PB - Institut za onkologiju, Sremska Kamenica T2 - Archive of Oncology T1 - Assessment of toxic elements' content in swine kidneys: Pathomorphological analysis EP - 22 IS - 1-2 SP - 17 VL - 18 DO - 10.2298/AOO1002017M UR - conv_695 ER -
@article{ author = "Milićević, Dragan R. and Jovanović, Milijan and Jurić, Verica B. and Petrović, Zoran I. and Vuković, Dubravka", year = "2010", abstract = "Background: In order to ensure the safety of consumers in Serbia, the toxic elements' (Cd, Hg, As, Pb) content in swine kidneys collected from three different sites in Serbia (n=90), were determined by atomic absorption spectrometry. Also, in order to find information on the effects of accumulation of toxic elements in swine kidneys, histopathological examination of kidneys was carried out. Methods: Determination of toxic elements (Cd, Hg, As, Pb) in swine kidneys was performed by atomic absorption spectrometry. For microscopic examination, kidney samples were fixed in 10% neutral buffered formalin and absolute alcohol for 5 to 7 days, processed by routine methods, sectioned at 5-8 μm, and stained with hematoxylin and eosin (HE) for light microscopy. Results: The presence of mercury was found in 33.3% of kidney samples in the range of 0.005-0.055 mg/kg, while presence of cadmium was found in less degree (27.7%) but in higher content (0.05-1,23 mg/kg). The presence of arsenic was found only in one sample, while presence of lead was not found. The metal-to-metal correlation analysis supported the theory that there were different sources of contamination. Histopathological examination of kidneys confirms tubulopathies with edema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules' cells were found. Conclusion: This study shows the presence of toxic elements in pigs butchered in Serbia at levels comparable to those reported in other countries., and consequently do not represent any concern from a consumer safety point of view. The lack of strong correlation between histopathological changes and incidence of toxic elements found in our trial may explain the possible synergism among toxic elements and other nephrotoxic compounds, which enhances the toxicity, especially in cases of low contamination.", publisher = "Institut za onkologiju, Sremska Kamenica", journal = "Archive of Oncology", title = "Assessment of toxic elements' content in swine kidneys: Pathomorphological analysis", pages = "22-17", number = "1-2", volume = "18", doi = "10.2298/AOO1002017M", url = "conv_695" }
Milićević, D. R., Jovanović, M., Jurić, V. B., Petrović, Z. I.,& Vuković, D.. (2010). Assessment of toxic elements' content in swine kidneys: Pathomorphological analysis. in Archive of Oncology Institut za onkologiju, Sremska Kamenica., 18(1-2), 17-22. https://doi.org/10.2298/AOO1002017M conv_695
Milićević DR, Jovanović M, Jurić VB, Petrović ZI, Vuković D. Assessment of toxic elements' content in swine kidneys: Pathomorphological analysis. in Archive of Oncology. 2010;18(1-2):17-22. doi:10.2298/AOO1002017M conv_695 .
Milićević, Dragan R., Jovanović, Milijan, Jurić, Verica B., Petrović, Zoran I., Vuković, Dubravka, "Assessment of toxic elements' content in swine kidneys: Pathomorphological analysis" in Archive of Oncology, 18, no. 1-2 (2010):17-22, https://doi.org/10.2298/AOO1002017M ., conv_695 .