dc.description.abstract | Mannan-oligosaccharides (MOS) are prebiotics that may
prevent bacterial adhesion to mucosal surfaces and neutralize their toxins
without causing tissue damage. For that reason, they have been used as feed
additives for more than 20 years. They exert positive influence on animals
by selective stimulation of growth and/or activity of one or limited number
of non pathogenic bacteria in the digestive tract. Systemic positive effects
of MOS may be attributed to absorption of bacterial fermentation products
and by improving hosts health status.
Addition of mannan-oligosaccharides (MOS) to cow's colostrum (5
g/L) resulted in significant enhancement of IgG concentration in neonatal
calf’s sera. Calves were fed colostrum, supplemented with Bio-Mos (5g/L),
three times during the first 24 hrs of life and Ig G concentration was
determined at 6, 12, 24 and 48h following birth.
Same phenomenon was documented in numerous experiments on
piglets which were allowed to suckle free, followingper oral application of
MOS suspension. Piglets were orally dosed with 10 mL of a 75g/L mannanoligosaccharide
suspension in saline water at parturition and 12 hrs after
birth. In the piglet’s trial, blood samples were collected only 48h after birth.
In our trials, IgG concentration was measured by radial immunodiffusion
(anti-bovine and anti-pig IgG RID plates, INEP, Zemun). In
treated, calves and piglets, a significant improvement in IgG sera
concentration was achieved. Titersof the antiBHV-1 antibodies in the
calvessera 24 hrs after birth and after 7 days, were higher in the Bio-Mosfed
group and differences were statistically significant when compared to the
control group. Improvement of passive immunological transfer significantly
reduced calves mortality rate on the farm.
We have also investigated possibilities for therapy of sows, suffering
from puerperal endometritis by intra uterine application of sterile MOS
suspension. We have used MOS-based product (Yeast Call Wall, Alltech,
Fermin, Senta) in the amounts of 5, 10 and 20g (I, II and III group)
suspended in 100 mL of saline. In groups II and III we noted significant clinical improvement in treated sows and moreover higher body weight
gain in piglets. | sr |