Fowl adenovirus infection - potential cause of a suppressed humoral immune response of broilers to newcastle disease vaccination
2023
Аутори
Maletić, JelenaSpalević, Ljiljana
Kureljušić, Branislav
Veljović, Ljubiša
Maksimović Zorić, Jelena
Maletić, Milan
Milićević, Vesna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity.In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera.... Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (>= 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera.The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control.
Кључне речи:
vaccination / Newcastle disease / immunosuppression / Fowl ad enovirusesИзвор:
Acta Veterinaria-Beograd, 2023, 73, 1, 133-142Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200030 (Научни институт за ветеринарство Србије, Београд) (RS-MESTD-inst-2020-200030)
DOI: 10.2478/acve-2023-0010
ISSN: 0567-8315
WoS: 000952407400010
Scopus: 2-s2.0-85150156060
Институција/група
Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Maletić, Jelena AU - Spalević, Ljiljana AU - Kureljušić, Branislav AU - Veljović, Ljubiša AU - Maksimović Zorić, Jelena AU - Maletić, Milan AU - Milićević, Vesna PY - 2023 UR - https://reponivs.nivs.rs/handle/123456789/494 AB - Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity.In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (>= 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera.The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - Fowl adenovirus infection - potential cause of a suppressed humoral immune response of broilers to newcastle disease vaccination EP - 142 IS - 1 SP - 133 VL - 73 DO - 10.2478/acve-2023-0010 UR - conv_604 ER -
@article{ author = "Maletić, Jelena and Spalević, Ljiljana and Kureljušić, Branislav and Veljović, Ljubiša and Maksimović Zorić, Jelena and Maletić, Milan and Milićević, Vesna", year = "2023", abstract = "Fowl adenovirus infections have a significant economic impact, especially in the production of broilers. It is considered the leading cause of three syndromes: adenoviral gizzard erosions and ulcerations, inclusion body hepatitis, and hepatitis-hydropericardium syndrome. A critical feature of this virus is its immunosuppressive effect, via suppressing humoral and cellular immunity.In this study, we examined the humoral immune response after administration of the Newcastle disease vaccine in broiler flocks with previously confirmed seroconversion against Fowl adenovirus. The study was conducted on 5 farms. A total of 220 chickens, five weeks of age, showing no clinical signs of the disease, were included in this study. The control group consisted of 20 chickens from a negative farm. Chickens were vaccinated with commercially available live NDV vaccines between 11 and 13 days of life. ELISA determined the presence of specific antibodies against FAdV in a total of 130/200 (65%) blood sera. Depending on the farm, seroprevalence ranged from 30-100%. The presence of specific antibodies against NDV was determined three weeks after vaccination using the hemagglutination inhibition assay. A positive hemagglutination inhibition (HI) titer (>= 16) was found in 41/200 (20.5%) sera, which was significantly less compared to the control farm, where a positive HI titer was found in 20/20 (100%) sera.The results of our study indicate the immunosuppressive effect of FAdV in subclinically infected birds and highlight the need for its diagnosis, prevention, and control.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "Fowl adenovirus infection - potential cause of a suppressed humoral immune response of broilers to newcastle disease vaccination", pages = "142-133", number = "1", volume = "73", doi = "10.2478/acve-2023-0010", url = "conv_604" }
Maletić, J., Spalević, L., Kureljušić, B., Veljović, L., Maksimović Zorić, J., Maletić, M.,& Milićević, V.. (2023). Fowl adenovirus infection - potential cause of a suppressed humoral immune response of broilers to newcastle disease vaccination. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 73(1), 133-142. https://doi.org/10.2478/acve-2023-0010 conv_604
Maletić J, Spalević L, Kureljušić B, Veljović L, Maksimović Zorić J, Maletić M, Milićević V. Fowl adenovirus infection - potential cause of a suppressed humoral immune response of broilers to newcastle disease vaccination. in Acta Veterinaria-Beograd. 2023;73(1):133-142. doi:10.2478/acve-2023-0010 conv_604 .
Maletić, Jelena, Spalević, Ljiljana, Kureljušić, Branislav, Veljović, Ljubiša, Maksimović Zorić, Jelena, Maletić, Milan, Milićević, Vesna, "Fowl adenovirus infection - potential cause of a suppressed humoral immune response of broilers to newcastle disease vaccination" in Acta Veterinaria-Beograd, 73, no. 1 (2023):133-142, https://doi.org/10.2478/acve-2023-0010 ., conv_604 .