Chronic wound dressings-Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels
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Аутори
Zmejkoski, Danica Z.![](/themes/Miragereponivs/images/orcid.png)
Zdravković, Nemanja
![](/themes/Miragereponivs/images/orcid.png)
Trisić, Dijana D.
![](/themes/Miragereponivs/images/orcid.png)
Budimir, Milica D.
![](/themes/Miragereponivs/images/orcid.png)
Marković, Zoran M.
![](/themes/Miragereponivs/images/orcid.png)
Kozyrovska, Natalia O.
![](/themes/Miragereponivs/images/orcid.png)
Todorovic-Marković, Biljana M.
![](/themes/Miragereponivs/images/orcid.png)
Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents. New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) - BC-Chi and chitosan nanoparticles (nChiD) - BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro ...healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents.
Кључне речи:
Dressings / Chronic wound treatment / Chitosan polymer and nanoparticles / Bacterial cellulose / Anti-biofilm activityИзвор:
International Journal of Biological Macromolecules, 2021, 191, 315-323Издавач:
- Elsevier, Amsterdam
DOI: 10.1016/j.ijbiomac.2021.09.118
ISSN: 0141-8130
PubMed: 34562533
WoS: 000710246700008
Scopus: 2-s2.0-85115811700
Институција/група
Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Zmejkoski, Danica Z. AU - Zdravković, Nemanja AU - Trisić, Dijana D. AU - Budimir, Milica D. AU - Marković, Zoran M. AU - Kozyrovska, Natalia O. AU - Todorovic-Marković, Biljana M. PY - 2021 UR - https://reponivs.nivs.rs/handle/123456789/446 AB - Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents. New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) - BC-Chi and chitosan nanoparticles (nChiD) - BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents. PB - Elsevier, Amsterdam T2 - International Journal of Biological Macromolecules T1 - Chronic wound dressings-Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels EP - 323 SP - 315 VL - 191 DO - 10.1016/j.ijbiomac.2021.09.118 UR - conv_574 ER -
@article{ author = "Zmejkoski, Danica Z. and Zdravković, Nemanja and Trisić, Dijana D. and Budimir, Milica D. and Marković, Zoran M. and Kozyrovska, Natalia O. and Todorovic-Marković, Biljana M.", year = "2021", abstract = "Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents. New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) - BC-Chi and chitosan nanoparticles (nChiD) - BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents.", publisher = "Elsevier, Amsterdam", journal = "International Journal of Biological Macromolecules", title = "Chronic wound dressings-Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels", pages = "323-315", volume = "191", doi = "10.1016/j.ijbiomac.2021.09.118", url = "conv_574" }
Zmejkoski, D. Z., Zdravković, N., Trisić, D. D., Budimir, M. D., Marković, Z. M., Kozyrovska, N. O.,& Todorovic-Marković, B. M.. (2021). Chronic wound dressings-Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels. in International Journal of Biological Macromolecules Elsevier, Amsterdam., 191, 315-323. https://doi.org/10.1016/j.ijbiomac.2021.09.118 conv_574
Zmejkoski DZ, Zdravković N, Trisić DD, Budimir MD, Marković ZM, Kozyrovska NO, Todorovic-Marković BM. Chronic wound dressings-Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels. in International Journal of Biological Macromolecules. 2021;191:315-323. doi:10.1016/j.ijbiomac.2021.09.118 conv_574 .
Zmejkoski, Danica Z., Zdravković, Nemanja, Trisić, Dijana D., Budimir, Milica D., Marković, Zoran M., Kozyrovska, Natalia O., Todorovic-Marković, Biljana M., "Chronic wound dressings-Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels" in International Journal of Biological Macromolecules, 191 (2021):315-323, https://doi.org/10.1016/j.ijbiomac.2021.09.118 ., conv_574 .