Occurrence of ochratoxin A and heavy metals in tissues associated with porcine nephropathy in Serbia
Само за регистроване кориснике
2009
Аутори
Milicević, DraganJurić, Verica B.
Stefanović, Srđan
Jovanović, M.
Petrović, Zoran I.
Vuković, Dubravka
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In order to find information on the occurrence of mycotoxic porcine nephropathy in Serbia, during a six month period (2006/2007) samples of blood, kidney and liver from individual animals were collected from healthy slaughtered pigs (n=90) and analysed by HPLC for ochratoxin A (OTA). In addition, the presence of nephrotoxic heavy metals such as cadmium, lead, mercury and arsenic were measured and the kidneys pathohistologically examined. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g. The incidence of OTA in serum and kidney were very similar (30 and 31.1%), but varied between 0.24-220.8 ng/ml and 0.17-52.5 ng/g, respectively. The presence of mercury was confirmed in 33.3% of kidney samples and concentrations ranged between 0.005-0.055 mg/kg, while cadmium was found less frequently (27.7% positive samples) but at higher levels (0.05-1.23 mg/kg). The presence of arsenic was found in only one sample, while lead was not detected in any sample. Histopathologica...l examination of kidneys confirmed tubulopathies with oedema and cell vacuolisation. In addition, haemorrhages and necrosis of proximal kidney tubules' cells were found. These findings indicate that it is likely that most of the kidney injury is related to OTA and other nephrotoxic compounds which enhance the toxicity of OTA.
Кључне речи:
swine / residue / ochratoxin A / nephropathy / heavy metalsИзвор:
World Mycotoxin Journal, 2009, 2, 3, 347-356Издавач:
- Wageningen Academic Publishers, Wageningen
Финансирање / пројекти:
- Institute of Meat Hygiene and Technology, Belgrade
DOI: 10.3920/WMJ2008.1074
ISSN: 1875-0710
WoS: 000282995500010
Scopus: 2-s2.0-70350324889
Институција/група
Naučni institut za veterinarstvo SrbijeTY - JOUR AU - Milicević, Dragan AU - Jurić, Verica B. AU - Stefanović, Srđan AU - Jovanović, M. AU - Petrović, Zoran I. AU - Vuković, Dubravka PY - 2009 UR - https://reponivs.nivs.rs/handle/123456789/130 AB - In order to find information on the occurrence of mycotoxic porcine nephropathy in Serbia, during a six month period (2006/2007) samples of blood, kidney and liver from individual animals were collected from healthy slaughtered pigs (n=90) and analysed by HPLC for ochratoxin A (OTA). In addition, the presence of nephrotoxic heavy metals such as cadmium, lead, mercury and arsenic were measured and the kidneys pathohistologically examined. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g. The incidence of OTA in serum and kidney were very similar (30 and 31.1%), but varied between 0.24-220.8 ng/ml and 0.17-52.5 ng/g, respectively. The presence of mercury was confirmed in 33.3% of kidney samples and concentrations ranged between 0.005-0.055 mg/kg, while cadmium was found less frequently (27.7% positive samples) but at higher levels (0.05-1.23 mg/kg). The presence of arsenic was found in only one sample, while lead was not detected in any sample. Histopathological examination of kidneys confirmed tubulopathies with oedema and cell vacuolisation. In addition, haemorrhages and necrosis of proximal kidney tubules' cells were found. These findings indicate that it is likely that most of the kidney injury is related to OTA and other nephrotoxic compounds which enhance the toxicity of OTA. PB - Wageningen Academic Publishers, Wageningen T2 - World Mycotoxin Journal T1 - Occurrence of ochratoxin A and heavy metals in tissues associated with porcine nephropathy in Serbia EP - 356 IS - 3 SP - 347 VL - 2 DO - 10.3920/WMJ2008.1074 UR - conv_378 ER -
@article{ author = "Milicević, Dragan and Jurić, Verica B. and Stefanović, Srđan and Jovanović, M. and Petrović, Zoran I. and Vuković, Dubravka", year = "2009", abstract = "In order to find information on the occurrence of mycotoxic porcine nephropathy in Serbia, during a six month period (2006/2007) samples of blood, kidney and liver from individual animals were collected from healthy slaughtered pigs (n=90) and analysed by HPLC for ochratoxin A (OTA). In addition, the presence of nephrotoxic heavy metals such as cadmium, lead, mercury and arsenic were measured and the kidneys pathohistologically examined. Of the 90 liver samples, 26.6% contained OTA in the range of 0.22-14.5 ng/g. The incidence of OTA in serum and kidney were very similar (30 and 31.1%), but varied between 0.24-220.8 ng/ml and 0.17-52.5 ng/g, respectively. The presence of mercury was confirmed in 33.3% of kidney samples and concentrations ranged between 0.005-0.055 mg/kg, while cadmium was found less frequently (27.7% positive samples) but at higher levels (0.05-1.23 mg/kg). The presence of arsenic was found in only one sample, while lead was not detected in any sample. Histopathological examination of kidneys confirmed tubulopathies with oedema and cell vacuolisation. In addition, haemorrhages and necrosis of proximal kidney tubules' cells were found. These findings indicate that it is likely that most of the kidney injury is related to OTA and other nephrotoxic compounds which enhance the toxicity of OTA.", publisher = "Wageningen Academic Publishers, Wageningen", journal = "World Mycotoxin Journal", title = "Occurrence of ochratoxin A and heavy metals in tissues associated with porcine nephropathy in Serbia", pages = "356-347", number = "3", volume = "2", doi = "10.3920/WMJ2008.1074", url = "conv_378" }
Milicević, D., Jurić, V. B., Stefanović, S., Jovanović, M., Petrović, Z. I.,& Vuković, D.. (2009). Occurrence of ochratoxin A and heavy metals in tissues associated with porcine nephropathy in Serbia. in World Mycotoxin Journal Wageningen Academic Publishers, Wageningen., 2(3), 347-356. https://doi.org/10.3920/WMJ2008.1074 conv_378
Milicević D, Jurić VB, Stefanović S, Jovanović M, Petrović ZI, Vuković D. Occurrence of ochratoxin A and heavy metals in tissues associated with porcine nephropathy in Serbia. in World Mycotoxin Journal. 2009;2(3):347-356. doi:10.3920/WMJ2008.1074 conv_378 .
Milicević, Dragan, Jurić, Verica B., Stefanović, Srđan, Jovanović, M., Petrović, Zoran I., Vuković, Dubravka, "Occurrence of ochratoxin A and heavy metals in tissues associated with porcine nephropathy in Serbia" in World Mycotoxin Journal, 2, no. 3 (2009):347-356, https://doi.org/10.3920/WMJ2008.1074 ., conv_378 .