dc.creator | Glišić, Dimitrije | |
dc.creator | Kuručki, Milica | |
dc.creator | Ćirović, Duško | |
dc.creator | Šolaja, Sofija | |
dc.creator | Mirčeta, Jovan | |
dc.creator | Milićević, Vesna | |
dc.date.accessioned | 2024-09-25T09:56:02Z | |
dc.date.available | 2024-09-25T09:56:02Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 1746-6148 | |
dc.identifier.uri | https://reponivs.nivs.rs/handle/123456789/1095 | |
dc.description.abstract | Canine distemper virus (CDV) is a highly contagious and often fatal disease affecting wild and domesticated carnivores.
The virus is a single-stranded RNA virus from the genus Morbillivirus and the family Paramyxoviridae. While
domestic dogs are the most common hosts, the virus poses a significant threat to endangered wildlife due to its
broad host range. This study aimed to characterize the CDV Haemagglutinin (H) gene in golden jackals and explore
the molecular evolution of the virus in an underrepresented host. A total of 88 brain samples from hunted golden
jackals were tested for the presence of CDV viral nucleic acid, and the H gene of positive samples was amplified
and sequenced using the Sanger method. Phylogenetic analysis, conducted using maximum likelihood methods,
revealed that all Serbian sequences clustered within the Arctic lineage. Notably, the analysis identified a tyrosine (Y)
at position 549 of the H protein, a mutation commonly associated with wildlife hosts, instead of the histidine (H) typically
found in domestic strains. Additionally, a mutation at position 310 was observed, which could potentially affect
the protein’s function and virus-host interactions. These findings provide valuable insights into the genetic diversity
and evolutionary dynamics of CDV in golden jackals, with broader implications for understanding the virus’s adaptability
to different hosts. Further research is needed to investigate the functional impact of these mutations, particularly
their role in vaccine efficacy and disease transmission across wildlife and domestic species. | sr |
dc.language.iso | en | sr |
dc.publisher | BioMed Central (BMC) | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200030/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | BMC Veterinary Research | sr |
dc.subject | Canine distemper virus | sr |
dc.subject | Golden jackal | sr |
dc.subject | Phylogenetic analysis | sr |
dc.subject | Mutation analysis | sr |
dc.subject | Serbia | sr |
dc.title | Molecular analysis of canine distemper virus H gene in the golden jackal (Canis aureus) population from Serbia | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.citation.spage | 426 | |
dc.citation.volume | 20 | |
dc.identifier.doi | 10.1186/s12917-024-04284-5 | |
dc.identifier.fulltext | http://reponivs.nivs.rs/bitstream/id/3013/s12917-024-04284-5.pdf | |
dc.type.version | publishedVersion | sr |